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DAO 59:171-174 (2004)
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Abstract
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In vitro effects of the polyphenols resveratrol, mangiferin and
(–)-epigallocatechin-3-gallate on the scuticociliate fish pathogen Philasterides dicentrarchi
J. Leiro*, J. A. Arranz, A. Paramá, M. F. Álvarez, M. L. Sanmartín
Laboratorio de Parasitología, Instituto de Investigación y Análisis Alimentarios, Universidad de Santiago de Compostela, Constantino Candeira 15782, Santiago de Compostela, Spain
*Email: mpleiro@usc.es
ABSTRACT: This study investigated the in vitro effects of the polyphenols resveratrol, mangiferin and (–)-epigallocatechin-3-gallate (EGCG) on the histiophagous ciliate Philasterides dicentrarchi, which causes fatal scuticociliatosis
in farmed turbot Scophthalmus maximus L. Of the 3 polyphenols, resveratrol showed strongest antiprotozoal activity, reducing ciliate density after 1 wk culture by, on average, 91% at 50 µM, and 96% at 500 µM. EGCG reduced ciliate density by, on
average, 93% at 500 µM, with no significant effect at 50 µM. Mangiferin reduced ciliate density by, on average, 56% at 500 µM, again with no significant effect at 50 µM. In view of these findings, we discuss the potential utility of chemotherapy with
polyphenols as a strategy for the control of scuticociliatosis in farmed turbot.
KEY WORDS: Polyphenols · Philasterides dicentrarchi · Resveratrol · Mangiferin · Epigallocatechin
Full text in pdf format
Published in DAO Vol.
59, No. 2
(2004) on May 5
Print ISSN: 0177-5103; Online ISSN: 1616-1580.
Copyright © Inter-Research, Oldendorf/Luhe, 2004
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