IR Home
DAO
Home
Editors
Forthcoming
Information
Journals
Home
MEPS
AME
CR
DAO
ESEP
Search
Subscribe
Book Series
EE Books
Top Books
ESEP Books
Order
EEIU Brochures
(pdf format)
Discussion Forums
Home
Research
Endangered Species Programs
Institutions
International Ecology Institute
Eco-Ethics International Union
Foundation
Otto Kinne Foundation
 | |
DAO 56:195-200 (2003)
|
Abstract
|
Effect of intraperitoneally administered IL-1b-derived peptides on resistance to viral haemorrhagic septicaemia in rainbow trout Oncorhynchus mykiss
Scott Peddie1,3, Pamela E. McLauchlan1,2, Anthony E. Ellis2, Christopher J. Secombes1,*
1School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK
2SEERAD Marine Laboratory, PO Box 101, Victoria Road, Aberdeen AB11 9DB, UK
3Present address: Animal Health Economics Group, Research & Development Division, Scottish Agricultural College, Aberdeen AB21 9YA, UK
*Corresponding author. Email: c.secombes@abdn.ac.uk
ABSTRACT: The present work provides the first information concerning the immunostimulatory activity of trout interleukin (IL)-1b-derived peptides in vivo. Previous studies have demonstrated the ability of 2 such peptides,
referred to as P1 and P3, to up-regulate a range of important immune parameters in vitro. P1 corresponds to fragment 146-157 (YVTPVPIETEAR) of the trout sequence and is analogous to a biologically active mammalian IL-1b-derived peptide, whilst P3 was synthesised to complex with the IL-1 receptor and corresponds to fragment 197-206 (YRRNTGVDIS) of the trout sequence. Optimal migration of peritoneal leucocytes, peptide induced phagocytosis and
intracellular respiratory burst activity occurred following intraperitoneal injection of 3.0 µmol of P3. Furthermore, resistance to viral haemorrhagic septicaemia virus (VHSV) was soon augmented (2 d) post-injection of P3.
KEY WORDS: Interleukin-1b · Phagocytosis · Respiratory burst · Disease resistance · Immunomodulation · VHS
Full text in pdf format
Published in DAO Vol.
56, No. 3
(2003) on October 24
Print ISSN: 0177-5103; Online ISSN: 1616-1580.
Copyright © Inter-Research, Oldendorf/Luhe, 2003
|
