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DAO 49:39-44 (2001)
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Abstract
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Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water
Sidsel Sohlberg1,*, Kristian Ingebrigtsen1, Magne K. Hansen1, William L. Hayton2, Tor Einar Horsberg1
1 Department of Pharmacology, Microbiology, and Food Hygiene, The Norwegian School of Veterinary Science, PO Box 8146 Dep., 0033 Oslo, Norway
2 Ohio State University, College of Pharmacy, Columbus, Ohio 43210, USA
*E-mail: sidsel.sohlberg@veths.no
ABSTRACT: 14C-labeled flumequine was administered as a single oral (5 mg kg-1, 86 µCi kg-1) or intravenous (5 mg kg-1, 82 µCi kg-1) dose to Atlantic salmon Salmo salar held in sea water or in
fresh water. The absorption, tissue distribution and elimination were determined by means of liquid scintillation counting and whole-body autoradiography. The drug was rapidly absorbed and extensively distributed in all groups of fish. Radiolabeled
compound was present in blood and muscle for more than 8 wk in the freshwater groups. In the seawater groups, however, no radioactivity was detected in the blood and muscle after 4 d and 2 wk, respectively. It was concluded that flumequine was eliminated
at a substantially higher rate from Atlantic salmon in sea water than in fresh water.
KEY WORDS: Flumequine · Kinetics · Whole-body autoradiography · Atlantic salmon
Full text in pdf format
Published in DAO Vol.
49, No. 1
(2001) on December 20
Print ISSN: 0177-5103; Online ISSN: 1616-1580.
Copyright © Inter-Research, Oldendorf/Luhe, 2001
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