Diseases of Aquatic Organisms
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Treatment of Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli by oral administration of praziquantel in combination with cimetidineKi Hong Kim*, Eun Hae Lee, Se Ryun Kwon, Jae Bum ChoDepartment of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Pusan 608-737, KoreaABSTRACT: The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orally administered praziquantel alone (50, 100 and 200 mg kg-1 body wt, BW) or in combination with cimetidine at a dose of 200 mg kg-1 BW for each praziquantel dose. The fish in the control group were administered only saline. The results clearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administration times and costs for the treatment of M. sebastis infestation in cultured rockfish.
KEY WORDS: Praziquantel · Cimetidine · Microcotyle sebastis · Sebastes schlegeli · Treatment efficacy
Published in DAO Vol.
44, No. 2
(2001) on March 9
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